The Mechanisms of Placental Viral Infection
- 1 September 2001
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 943 (1), 148-156
- https://doi.org/10.1111/j.1749-6632.2001.tb03798.x
Abstract
The placenta is a dynamic organ whose structure and function change throughout pregnancy. There is compelling evidence that the placenta plays an integral role in the vertical transmission of viruses, such as cytomegalovirus and human immunodeficiency virus, from the mother to the fetus. Although the sequelae of congenital viral infection (i.e., fetal anomalies, intrauterine fetal death, and persistent postnatal infection) may be devastating, very little is known about the passage of viruses across the placenta and the pathologic consequences of placental viral infection. We postulate that the syncytiotrophoblast, which forms a continuous barrier between the maternal and fetal circulation, is relatively resistant to viral infection. In support of this hypothesis, we observed that the susceptibility of trophoblast cells to infection by adenovirus and herpes simplex virus and the expression of viral receptors were reduced as trophoblast cells terminally differentiated into syncytiotrophoblast. Conversely, we observed that undifferentiated, extravillous trophoblast cells, which are susceptible to adenovirus infection, underwent pathologic changes (i.e., apoptosis) when infected by adenovirus in the presence of decidual lymphocytes (which were used to simulate the maternal immune response to viral infection). Based on these findings, we speculate that viral infection of extravillous trophoblast cells may negatively impact the process of placental invasion and predispose the mother and fetus to adverse reproductive outcomes that result from placental dysfunction.This publication has 40 references indexed in Scilit:
- Detection of Intrauterine Viral Infection Using the Polymerase Chain ReactionMolecular Genetics and Metabolism, 1998
- Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5Science, 1997
- Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target CellsScience, 1996
- Transduction of Human Trophoblast Cells by Recombinant Adenoviruses is Differentiation Dependent1Biology of Reproduction, 1996
- Human trophoblast adhesion to osteopontin is regulated by cell differentiation and divalent cationsJournal of the Society for Gynecologic Investigation, 1995
- Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachmentCell, 1993
- Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.JCI Insight, 1992
- Intrauterine herpes simplex virus infectionsThe Journal of Pediatrics, 1987
- Cervical and serum IgA and serum IgG antibodies to Chlamydia trachomatis and herpes simplex virus in threatened abortion: a prospective studyBJOG: An International Journal of Obstetrics and Gynaecology, 1983
- Congenital Herpes Simplex Type II Infection with Extensive Hepatic Calcification, Bone Lesions and Cataracts: Complete Postmortem ExaminationDevelopmental Medicine and Child Neurology, 1977