Chronic progressive myelopathy associated with HTLV‐I
- 1 December 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (12), 1566
- https://doi.org/10.1212/wnl.39.12.1566
Abstract
Among 22 patients with human T-lymphotropic virus type I (HTLV-I)-associated chronic progressive myelopathy, agarose isoelectric focusing (AIF) revealed oligoclonal IgG bands in 21: in 3 in CSF only; in 11 in CSF and to some extent in serum; and in 7, identical patterns in CSF and serum. By immunoblot after AIF of CSF and serum, we observed bands of anti-HTLV-I IgG antibodies in 19 patients: in 5 in CSF only; in 9 in CSF and partly in serum; and in 5, identical in CSF and serum. Oligoclonal anti-HTLV-I IgG antibody bands could only partly be traced to oligoclonal IgG bands. If, prior to AIF, serum and CSF were absorbed with HTLV-I antigen, practically all oligoclonal HTLV-I-specific IgG antibody activity was abolished, while the oligoclonal pattern of total IgG was affected only to a minor extent. Alongside with HTLV-I-specific oligoclonal B cell response, HTLV-I myelopathy is regularly accompanied by production of oligoclonal IgG of unknown antibody specificities.This publication has 11 references indexed in Scilit:
- Clinical picture of HTLV-I associated myelopathyJournal of the Neurological Sciences, 1988
- Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV‐I‐associated myelopathyNeurology, 1988
- Intrathecal Synthesis of Antibodies to Human T Lymphotropic Virus Type I and the Presence of IgG Oligoclonal Bands in the Cerebrospinal Fluid of Patients with Endemic Tropical Spastic ParaparesisThe Journal of Infectious Diseases, 1988
- Oligoclonal IgG Bands in Cerebrospinal FluidArchives of Neurology, 1987
- Immunoblot detection of oligoclonal anti‐myelin basic protein IgG antibodies in cerebrospinal fluid in multiple sclerosisNeurology, 1987
- ANTIBODY TO HUMAN T-LYMPHOTROPIC VIRUS TYPE 1 IN WEST-INDIAN-BORN UK RESIDENTS WITH SPASTIC PARAPARESISThe Lancet, 1987
- Chronic progressive myelopathy associated with elevated antibodies to human T‐lymphotropic virus type I and adult T‐cell leukemialike cellsAnnals of Neurology, 1987
- Immunoglobulin abnormalities in the cerebrospinal fluid during bacterial meningitisJournal of Neuroimmunology, 1986
- ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESISThe Lancet, 1985
- Predominance of Oligoclonal IgG Type in CSF in Aseptic MeningitisArchives of Neurology, 1979