Isolated Hypoaldosteronism in Adults
- 21 September 1972
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 287 (12), 573-578
- https://doi.org/10.1056/nejm197209212871201
Abstract
To clarify the mechanism causing isolated hypoaldosteronism in adults, we studied six patients with unexplained hyperkalemia. On a normal sodium intake, excretion of tetrahydrodeoxycorticosterone, tetrahydrocorticosterone, and 17-hydroxycorticoids was normal and increased normally with ACTH stimulation. Excretion of metabolites of aldosterone and 18-hydroxycorticosterone was subnormal or barely normal, and aldosterone excretion failed to respond normally to sodium depletion and ACTH. Plasma renin activity (PRA) and concentration were subnormal and failed to increase normally with upright posture and sodium depletion; furosemide increased PRA in only one patient. Restoration of normal serum potassium with cation exchange resin failed to increase PRA in the three patients studied. Plasma renin substrate was normal or slightly elevated.Keywords
This publication has 29 references indexed in Scilit:
- The Regulation of Aldosterone Secretion in Anephric ManJCI Insight, 1971
- The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjectsJCI Insight, 1970
- Selective Aldosterone Deficiency in Chronic PyelonephritisNephron, 1970
- The juxtaglomerular apparatus in Addison's diseaseThe Journal of Pathology and Bacteriology, 1968
- Aldosterone Deficiency in Chronic Renal FailureNephron, 1968
- Aldosterone excretion in normal children and in children with adrenal hyperplasia.JCI Insight, 1966
- EFFECT OF ANGIOTENSIN AND OF FRUSEMIDE ON PLASMA ALDOSTERONE, CORTICOSTERONE, CORTISOL, AND RENIN IN MANThe Lancet, 1965
- The Effect of Angiotensin II on the Blood Pressure in Humans with Hypertensive Disease*JCI Insight, 1964
- THE EFFECTS OF ALTERATIONS OF PLASMA SODIUM AND POTASSIUM CONCENTRATION ON ALDOSTERONE SECRETION*JCI Insight, 1963
- IN VIVO AND IN VITRO STUDIES OF ADRENAL SECRETIONS IN CUSHING'S SYNDROME AND PRIMARY ALDOSTERONISM*JCI Insight, 1963