Bleeding Due to Increased Intravascular Blood Coagulation

Abstract

THROMBOSIS and hemorrhage are generally considered as diametrically opposed conditions. There is, however, a group of disorders in which generalized thrombosis and hemorrhagic tendency are intimately related. They are characterized by a hemorrhagic diathesis of acute onset and a clinical picture dominated by severe circulatory collapse. The pathogenesis of this syndrome is poorly understood, and only recently has it become clear that the hemorrhagic tendency is a consequence of the acute activation of the clotting mechanism, which results in the intravascular consumption of plasma clotting factors. In other words, the circulating plasma is transformed into circulating serum.This group . . .