Three chromosomes' (7;9;22) rearrangement and the origin of the Philadelphia chromosome
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 43 (2), 133-137
- https://doi.org/10.1007/bf00293590
Abstract
A woman with chronic myelocytic leukemia had the Philadelphia chromosome and a complex four-break—three-chromosome rearrangement. The q32→q34 portion of chromosome 9 is translocated to band q22 of chromosome 7, and at the end of this segment is attached the deleted q11→ qter portion of chromosome 22. A review of 12 cases of the Philadelphia chromosome originating by the rearrangement of three or more chromosomes reveals that chromosomes 9 and 22 are always involved, while the third chromosome is a different one in each case. We discuss the hypothesis that the 22q segment is always specifically attached to band 9q34 wherever this portion of 9q is transposed.This publication has 6 references indexed in Scilit:
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- A new translocation involving three chromosomes in chronic myelocytic leukemia, 46,XY,t(9;11;22)Cytogenetic and Genome Research, 1977
- A case of chronic myeloid leukemia with a translocation (12;22)(p13;q11)Human Genetics, 1977
- Chromosomes and causation of human cancer and leukemiaXVI. Banding studies of chronic myelocytic leukemia, including five unusual Ph1translocationsCancer, 1975
- Structural rearrangements associated with the Ph1 chromosome in chronic granulocytic leukaemiaHuman Genetics, 1975
- Two complex translocations in chronic granulocytic leukemia involving chromosomes 22, 9, and a third chromosomePublished by Springer Nature ,1975