The effect of preadministration ofCorynebacterium parvumon the protection afforded by heat-killed and acetone-killed vaccines against experimental mouse typhoid

Abstract

Mice given an intraperitoneal injection of 0.5 mg.Corynebacterium parvum(dry weight) before vaccination with heat-killed (HK) or acetone-killed (AK)Salmonella typhimuriumvaccine and later challenged intraperitoneally withS. typhimuriumstrain 1566, showed a statistically significant increase in mortality when compared with mice that had received onlyC. parvumbut no vaccine. They also showed a higher mortality rate than mice receiving only HK or AK vaccine or mice that had received no vaccine before challenge. Prior administration ofC. parvumto mice that are vaccinated with HK or AK vaccine appears to make them more susceptible to an intraperitoneal challenge withS. typhimurium. This was more apparent with HK vaccine than with AK vaccine.