Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2
- 1 December 1989
- journal article
- research article
- Published by Springer Nature in Current Genetics
- Vol. 16 (5-6), 315-321
- https://doi.org/10.1007/bf00340709
Abstract
Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNAfmet. The role of this enzyme in translational fidelity had not previously been suspected.This publication has 57 references indexed in Scilit:
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