ESTIMATION OF URINARY GONADOTROPIN OF THE NONPREGNANT HUMAN BY THE MOUSE UTERINE WEIGHT AND OVARIAN HYPEREMIA RESPONSES*

Abstract

Urinary excretion of material capable of causing ovarian hyperemia when injected into immature mice was studied Mouse uterine wt. assays were simultaneously performed. The material producing ovarian hyperemia is considered to be either luteinizing hormone or luteotrophin. The uterine wt. assay is thought to estimate total gonadotropin excreted. Normal women excrete at all times uterine wt.-increasing and ovarian hyperemia-producing materials, with a moderate increase in total gonadotropin and a proportionately much greater increase in hyperemia-producing material at ovulation. Less hyperemia-producing material is excreted by normal men. Female castrates excrete large amts. of total gonadotropin and small amts. of hyperemia-producing material. Estrogen therapy causes a reversion towards the normal pattern with production of large amts. of hyperemia-producing material.