The Modification of Diet in Renal Disease Study

Abstract

For reasons that are unknown, chronic kidney failure of diverse causes tends to progress to end-stage renal disease. Several hypotheses have been advanced to explain the mechanisms by which renal insufficiency progresses,^{1 2 3} but none have been definitely established.¹ Studies in animals⁴ and clinical trials in humans^{5 6 7} with chronic renal disease suggest that the dietary restriction of protein and phosphorus may slow the rate of progression. However, the trials of low-protein, low-phosphorus diets in humans have generally been deficient with respect to experimental design. The deficiencies include the lack of proper randomization procedures, absence or inappropriateness of control populations, use of . . .