Cortical biopsy results in Alzheimer's disease
- 1 July 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (7), 1201
- https://doi.org/10.1212/wnl.37.7.1201
Abstract
Neuropsychologic and pathologic data are presented for a group of 11 patients with a clinical diagnosis of probable Alzheimer's disease (AD) according to recently proposed criteria. In all cases, the diagnosis was verified by cortical biopsy. In addition, increased cortical plaque counts were associated with greater deficits in language production and comprehension and poorer performance on an index of global mental status. These results suggest that a clinical diagnosis of AD is very accurate when patient selection is restricted to typical cases and that language deficits may provide a useful indicator of severity of disease in AD patients.This publication has 8 references indexed in Scilit:
- Alzheimer's disease: a correlative study.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Neuropsychological syndromes in presenile dementia due to cerebral atrophy.Journal of Neurology, Neurosurgery & Psychiatry, 1986
- Heterogeneity in dementia of the Alzheimer typeNeurology, 1985
- Predictive features in mild senile dementia of the Alzheimer typeNeurology, 1984
- Forms of Memory FailureScience, 1983
- Accuracy of clinical diagnosis in primary degenerative dementia: correlation with neuropathological findings.Journal of Neurology, Neurosurgery & Psychiatry, 1983
- A New Clinical Scale for the Staging of DementiaThe British Journal of Psychiatry, 1982
- The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly SubjectsThe British Journal of Psychiatry, 1968