Chiral Separation of Cationic Drugs on an α1-Acid Glycoprotein Bonded Stationary Phase
- 1 February 1986
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 9 (2-3), 641-666
- https://doi.org/10.1080/01483918608076658
Abstract
A commercially available chiral stationary phase containing α1-acid glycoprotein on silica (EnantioPac, LKB) was applied to the resolution of a number of pharmacologically important enantiomeric ammonium compounds. The optimization of retention and selectivity by cationic, anionic and neutral modifiers in the mobile phase was studied. The results suggest that the solutes are retained according to an ion-pair distribution model. Compounds of widely different structures were studied, and high separation factors were achieved for a majority.This publication has 10 references indexed in Scilit:
- Determination of (R)- and (S)-Disophyramide in human plasma using a chiral α1-acid glycoprotein columnJournal of Chromatography B: Biomedical Sciences and Applications, 1984
- Stereoselective binding of propranolol enantiomers to human alpha 1‐ acid glycoprotein and human plasma.British Journal of Clinical Pharmacology, 1984
- Binding of oxprenolol and propranolol to serum, albumin and α1-acid glycoprotein in man and other speciesBiochemical Pharmacology, 1984
- Liquid chromatographic resolution of racemic drugs using chiral α1-acid glycoprotein columnJournal of Chromatography A, 1984
- Stereoselective binding of propranolol to human plasma, α1-acid glycoprotein, and albuminClinical Pharmacology & Therapeutics, 1983
- Direct liquid chromatographic resolution of racemic drugs using α1-acid glycoprotein as the chiral stationary phaseJournal of Chromatography A, 1983
- Chiral resolution of aminoalcohols by ion-pair chromatographyChromatographia, 1982
- Binding and Displacement of Basic, Acidic and Neutral Drugs in Normal and Orosomucoid-deficient PlasmaClinical Pharmacokinetics, 1981
- Retention behavior of carboxylic acids and their quaternary ammonium ion pairs in reversed phase chromatography with acetonitrile as organic modifier in the mobile phaseAnalytical Chemistry, 1979