THE EFFECT OF CHOLECYSTOKININ ON THE HUMAN GALL BLADDEE

Abstract

The gall bladder of man can be caused to contract and evacuate on the intravenous injection of a "purified" extract of the upper intestinal mucosa, the active principle of which has been called cholecystokinin. A method is described for preparing a cholecystokinin concentrate active in the dog in 3.0 to 1 mgm. doses, or 0.2 to 0.1 mgm. per kgm. body weight, and non-antigenic in the guinea pig and non-toxic in the dog, but which produces an occasional reaction in man.