A Glucose-Controlled Insulin-Delivery System: Semisynthetic Insulin Bound to Lectin
- 7 December 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 206 (4423), 1190-1191
- https://doi.org/10.1126/science.505005
Abstract
A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.Keywords
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