Low‐dose cyclosporin A microemulsion in children with severe atopic dermatitis: Clinical and immunological effects
- 1 August 2001
- journal article
- clinical trial
- Published by Wiley in Pediatric Allergy and Immunology
- Vol. 12 (4), 216-223
- https://doi.org/10.1034/j.1399-3038.2001.012004216.x
Abstract
Cyclosporin A (CsA) is an effective and well-tolerated treatment for severe childhood atopic dermatitis (AD). By starting at a low dose, the therapeutic safety should be further increased. The aim of this study was to evaluate low-dose CsA in childhood AD with respect to clinical outcome and modulation of T-cell dysregulation. In an open prospective study, 10 children (age: 22-106 months) with severe AD (mean objective SCORAD score > 40 on two baseline measurements at a minimum interval of 2 weeks) were treated with CsA solution for 8 weeks. All patients received a starting dose of 2.5 mg/kg/day, which was increased stepwise in non-responders to a maximum of dose of 5 mg/kg/day. Disease activity was monitored using the SCORAD index. The frequency of cytokine-producing peripheral blood T lymphocytes was analyzed by intracellular cytokine staining, and T-cell numbers were measured by fluorescence-activated cell sorter (FACS) analysis. Twenty healthy age-matched children were included as controls for the immunological data. Nine of the 10 patients had a SCORAD reduction of at least 35%. In seven patients this was achieved with low-dose CsA at 2.5 mg/kg/day (n = 4) and 3.5 mg kg/day (n = 3). Seven of the nine responders experienced no relapse within the 4-week follow-up period. At baseline the percentage of interleukin-4 (IL-4), IL-13, and human leucocyte antigen (HLA)-DR-positive CD3(+) cells was higher in the patient group than in the controls. After CsA treatment there was a significant reduction in interferon-gamma (IFN-gamma), IL-2, IL-4, IL-13, and HLA-DR-positive CD3(+) cells. Hence, in severe pediatric AD, CsA microemulsion, when started at a low dose (2.5 mg/kg/day), improves clinical measures of disease, reduces T-lymphocyte cytokine production, and regulates T-cell activation.Keywords
This publication has 34 references indexed in Scilit:
- Clinical Validation and Guidelines for the SCORAD Index: Consensus Report of the European Task Force on Atopic DermatitisDermatology, 1997
- Cyclosporine in severe childhood atopic dermatitis: A multicenter studyJournal of the American Academy of Dermatology, 1996
- A new microemulsion formulation of cyclosporin (Neoral) is effective in the treatment of cyclosporin-resistant dermatosesBritish Journal of Dermatology, 1996
- An immunohistochemical study of the dermal infiltrate and epidermal staining for interleukin 1 in 12 cases of Sweet's syndromeBritish Journal of Dermatology, 1996
- Cyclosporine A microemulsion in severe atopic dermatitisJournal of the European Academy of Dermatology and Venereology, 1995
- Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.JCI Insight, 1994
- Cyclosporin‐A in the treatment of atopic dermatitis: effects on the immune system and clinical efficiencyJournal of the European Academy of Dermatology and Venereology, 1994
- Cycloporin A Treatment of Severe Atopic Dermatitis in a ChildPediatric Dermatology, 1994
- Practical management of atopic eczemaThe Lancet, 1994