Metabolism of Sulfobromophthalein in Hepatectomized and Hepatectomized-Nephrectomized Dog.

Abstract

Conjugation and rate of removal of sulfobromophthalein (BSP) from the blood stream were studied in hepatectomized and hepatectomized-nephrectomized dogs. Clearance of BSP from the blood of hepatectomized dogs occurred at a slow but significant rate. Only 10% of the cleared dye was excreted in the urine. Conjugates of BSP appeared in the serum and in an even greater percentage in the urine. Hepatectomized dogs after nephrectomy still cleared BSP at a significant rate but had only questionable traces of metabolites in the serum. It was concluded that the kidney is capable of conjugating BSP but that most of the dye clearance in the hepatectomized dog can be attributed to extrarenal mechanisms in the peripheral tissues.