STIMULATING EFFECT OF SUGAR, FAT, AND MEAT MEALS ON DUODENAL SECRETION IN THE DOG

Abstract

The purpose of this study was to gain information concerning the secretagogue activity of "pure" foodstuffs on duodenal secretion. Sugar, fat, and meat meals were fed to dogs with either a duodenal pouch, or a duodenal flap, designed to simulate an everted pouch. The vol. of secretion from duodenal pouches increased markedly following the admn. of sugar, fat, meat, and mixed meals, and also following the intraven. injn. of SI, an intestinal extract, and the subcut. injn. of urecholine. The only effective stimulants for the flap prepns. were the mixed meal (slight response), and SI. The explanation offered is that the humoral agent, which has previously been proven to exist, has 2 factors: one stimulating secretion directly, and the other stimulating motility, which in the pouch causes rubbing together of the mucosal folds and incidental mechanical stimulation of secretion. The authors conclude that there is no single, specific secretagogue controlling Brunner''s gland secretion.