Prostacyclin and thromboxanes in carrageenan-induced pleurisy in the rat
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 14 (1), 76-81
- https://doi.org/10.1007/bf01966837
Abstract
The cellular origin and kinetics of TXB2 and 6-keto PGF1α in carrageenan-induced pleurisy has been studied. Maximum levels of these prostanoids occurred 1 hour after induction of pleurisy. Mononuclear cells initially present in the pleural cavity synthesized TXB2 and 6-keto PGF1α from (14C) arachidonic acid. By contrast, PMN cells harvested 6 hours after the induction of inflammation did not produce 6-keto-PGF1α. Selective inhibition of thromboxane synthetase with drugsin vitro andin vivo increased the formation of 6-keto-PGF1α, the stable breakdown product of PGI2. This metabolic effect was parallel to an increase in the volume of exudate and in PMN migration. These results suggest that TXA2 seems to be implicated not only as a chemotactic agent but also as an antagonist of PGI2 vasodilator effects.Keywords
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