Increased Serum Bile Acids in Cirrhosis with Normal Transaminases
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 25 (4), 217-221
- https://doi.org/10.1159/000198835
Abstract
Fasting and postprandial serum concentrations of total conjugated primary bile acids determined by radioimmunoassay have been compared with conventional liver function tests in patients with cirrhosis of the liver and normal transaminases. While γ-glutamyl-transferase had the highest sensitivity (69%) among the conventional liver function tests, it was much less sensitive for the detection of cirrhosis with normal transaminases than fasting (93% sensitivity) or postprandial (93% sensitivity) bile acid concentrations in serum. When a combination of fasting and postprandial bile acid concentrations was used, the sensitivity increased to 97%.Keywords
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