Perfluoroctylbromide as a Diagnostic Contrast Medium in Gastroenterography

Abstract

The efficacy and safety of perfluoroctylbromide as a diagnostic contrast medium for gastroenterography was studied in rats, dogs and guinea pigs. Perfluoroctylbromide possessed excellent coating properties and a short transit time in the gastrointestinal tract. The conscious animals tolerated 64 ml/kg without any toxic manifestations. Thorough hematologic, serologic and histologic examinations showed no evidence of any adverse effects. Perfluoroctylbromide may be especially useful in patients with advanced inflammatory lesions of the gastrointestinal tract or in those with risk of aspiration of contrast medium into the lungs during gastroenterographic examinations.