Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
- 1 November 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 348 (6300), 411-418
- https://doi.org/10.1038/348411a0
Abstract
The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.Keywords
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