DETECTION OF STREPTOCOCCAL GROUP-SPECIFIC ANTIBODIES IN HUMAN SERA

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Abstract
Two serologically distinct antibodies directed against different antigenic sites on the Group A carbohydrate were detected in human sera by agglutination techniques. Agglutinins with A-variant specificity were demonstrable by the direct agglutination of purified A-variant cell walls, whereas indirect Coombs-type agglutinins with Group A specificity were demonstrable with Group A cell walls. Selective adsorption with homologous cell walls as well as inhibition studies with the soluble carbohydrates confirmed the specificity of the two types of agglutinins.