A case of mucormycosis essentially localized to the mucosa of the palate and contiguous tissues has been reported in a 40-year-old diabetic female. Palatal bone had undergone necrosis, and maxillary sinus mucosa was also involved with lesions of mucormycosis. Diagnosis was carried out by culture of the organism and by microscopic studies utilizing appropriate staining techniques. Successful therapy was effected by the use of amphotericin B and regulation of the diabetic state. Negative biopsy was used as a measure for success of the therapy employed.