Effect of Amino Acid Imbalance on Course of Lansing Poliomyelitis in Mice.

Abstract

A decreased susceptibility to Lansing poliomyelitis, characterized by prolonged incubation and survival times, has been observed in mice fed excess methionine. To obtain this effect fully, a constinuous period of high methionine intake was necessary prior to inoculation. The addition of excess methionine to low tryptophan rations containing 6-methyl tryptophan resulted in a more marked protection against Lansing infection in mice than when the same amts. of methionine or 6-methyl tryptophan were fed alone.