Kinetics of intravenous mezlocillin in chronic hemodialysis patients
- 1 August 1979
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 26 (2), 228-231
- https://doi.org/10.1002/cpt1979262228
Abstract
The kinetics of intravenous mezlocillin was studied in 8 patients with creatinine clearances under 7 ml/min who were undergoing chronic hemodialysis. Kinetic parameters were determined using a 2-compartment linear model. The mezlocillin serum half-life (t½) in these patients ranged from 2.9 to 7.8 hr (mean, 5.4). The t½ decreased to l .57 ± 0.09 hr during dialysis. Approximately 18% of the dose was recovered in the dialysate in 4 hr of dialysis. There was a 30% reduction per hour in serum concentration. The kinetics of mezlocillin, due to removal by nonrenal mechanisms, more closely resemble the kinetics of penicillin G and ampicillin than of carbenicillin and ticarcillin. A dosage schedule for use of intravenous mezlocillin in patients undergoing hemodialysis is presented.This publication has 5 references indexed in Scilit:
- Pharmacokinetics of Mezlocillin in Healthy VolunteersAntimicrobial Agents and Chemotherapy, 1978
- Kinetics of mezlocillin and carbenicillinClinical Pharmacology & Therapeutics, 1978
- Ticarcillin for Treatment of Serious Infections with Gram-Negative BacteriaThe Journal of Infectious Diseases, 1976
- Pharmacodynamics of Carbenicillin in Hepatic and Renal FailureAnnals of Internal Medicine, 1970
- Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single CompartmentJournal of Pharmaceutical Sciences, 1968