Effect of Triiodothyronine and Cortisol on Intracellular Penetration of D-xylose

Abstract

Distribution of D-xylose in the uncut rat diaphragm was studied in vitro under different conditions. Epinephrine, triiodothyronine or cortisol had no effect on distribution of this sugar when administered in vitro. Triiodothyronine or cortisol, administered parenterally, increased the space occupied by D-xylose in the absence of insulin, and in the presence of insulin it resulted in comparatively small but consistant addition to the space occupied when insulin alone was used. A 24-hr. starvation period had no effect on sugar distribution whereas a 56-hr. period increased the xylose space in the absence of insulin and was quantitatively additive in its presence.