Thyrotropin releasing hormone (TRH) as a possible quick-acting but short-lasting antidepressant
- 1 May 1975
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 5 (4), 404-412
- https://doi.org/10.1017/s0033291700057032
Abstract
Synopsis: In a double reversal design the potency of thyrotropin releasing hormone (TRH) (500 μgintravenously) as a quick-acting antidepressive agent was evaluated. A first injection did seem to give rise to a very slight short-lasting effect, though this could not be ascertained clearly. There were no visible effects after a second injection. The thyroid stimulating hormone (TSH) response curve after TRH administration in the depressive patients group was blunted in comparison with that in a matched control group of normals.Keywords
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