An approach to peripheral vasodilator-.beta.-adrenergic blocking agents

Abstract

The syntheses of 2-phenyl- and 2-pyridyl-4-trifluoromethylimidazoles having a 3-tert-butylamino-2-hydroxypropoxy moiety attached to the aryl or heteroaryl substituent are described. Structure-activity relationships based on results from an evaluation of these compounds for antihypertensive, vasodilating and .beta.-adrenergic blocking activities in dogs and spontaneously hypertensive rats are discussed.