Assignment of the human phosphoserine phosphatase gene (PSP) to the pter→q22 region of chromosome 7

Abstract

Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. PSP expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Human PSP is expressed only when the pter→q22 segment of the human 7 and its enzyme marker qβ-glucuronidase (GUSB) are retained in cell hybrids. The structural gene, PSP_,is therefore assigned to this region of the human 7.