ARSPHENAMINE HYPERSENSITIVENESS IN GUINEA-PIGS

Abstract

In my first paper¹ dealing with this subject, it was shown that guinea-pigs treated intradermally with a solution of neoarsphenamine develop hypersensitiveness of the skin to this drug. This shows itself in certain pigs by a spontaneous flare-up at the site of the intradermal injection and by a strong inflammatory reaction of hypersensitvity in almost all the animals tested later with intradermal injections of neoarsphenamine. Furthermore, intracardial injections of neoarsphenamine caused eruptions of the skin of varying degrees of severity in some of the hypersensitive animals, and focal reactions at the sites of previous intradermal injections could often be observed both after intracardial and after intradermal injections of the same drug. All of these observations confirmed the reports of W. Frei.² It was suggested that all these phenomena of hypersensitiveness may be attributable to the various reactions that occur in different subjects, or at different times in the