MONOCYTE IGG RECEPTOR ACTIVITY, DYNAMICS, AND MODULATION - NORMAL INDIVIDUALS AND PATIENTS WITH GRANULOMATOUS DISEASES

Abstract

Studies of monocyte Ig[immunoglobulin]G receptor activity by titration of rabbit Forssman antibody and fluid phase inhibition with human IgG1 and IgG3 indicate increased activity for cells from patients with sarcoidosis in comparison to normal individuals. IgG receptor activity was also increased for cells from patients with tuberculosis and, to some degree, for Crohn''s disease patients. Monocyte C[complement component]C3 receptor activity is increased in sarcoidosis and Crohn''s disease. Following phagocytosis of latex particles, IgG receptor activity remains for monocytes from sarcoidosis patients; activity transiently disappears for monocytes from normal individuals. Incubation with multistranded polynucleotides increases IgG receptor activity for normal subjects and has no significant effect on cells from patients with sarcoidosis or Crohn''s diseases. Circulating monocytes from patients with sarcoidosis, Crohn''s disease and tuberculosis are apparently activated in vivo as reflected by increased IgG and C3 receptor activity.