Improved Preparation of Cyclohexylidene Derivatives of MYO-Imositol

Abstract
Condensation of myo-inositol with 1,1-dimethoxycyclohexane in the presence of Nafion-H affords directly 1,2-O-cyclohexylidene-myo-inositol in 45-50% yield, along with 1,2:3,4-, 1,2:4,5- and 1,2:5,6-di-O-cyclohexylidene-myo-inositols in lesser amounts.

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