Section of fibular nerve affects activity pattern and contractile properties of soleus motor units in adult rats

Abstract

Transection of the common fibular (FIB) nerve caused an immediate reduction in the total amount of soleus (SOL) motor unit activity, which declined further during the following 10 days and then remained stable at less than half of normal values. In addition, there was an immediate reduction in median impulse rate from about 20.0 to 14.9 Hz followed by a return to normal values during the first 10 days. Short interval (3-4 ms) double discharges, occurring either in isolation or at the same regular intervals as single impulses, were observed 2-5 days after FIB nerve section in a few motor units. Brief, high frequency impulse bursts with interspike intervals of 12-16 ms were observed in a few units from the third day and until the end of the experiment (up to 31 days). It was not established whether the high frequency discharge pattern occurred only in a fixed population of the SOL motor units, or whether the units could switch between high and low frequency activity. Two months after FIB nerve section, the SOL muscle in the same leg contracted faster than normal (mean isometric twitch contraction time 29.6 ms, n = 4; vs. 38.7 ms, n = 8), contained a larger than normal percentage of type II fibres (13-36 vs. 0-0.2%) and weighed less than the contralateral SOL muscles (180 vs. 206 mg). SOL muscles (n = 4) in the opposite leg were comparable to normal SOL muscles except for a small reduction in mean isometric twitch contraction time (35.5 ms).