Presynaptic Actions of D2-Like Receptors in the Rat Cortico-Striato-Globus Pallidus Disynaptic Connection In Vitro
Open Access
- 1 February 2009
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 101 (2), 665-671
- https://doi.org/10.1152/jn.90806.2008
Abstract
The cerebral cortex, the neostriatum (Str), and the external segment of the globus pallidus (GPe) form a cortico-Str-GPe disynaptic connection, which is one of the major connections in the basal ganglia circuitries and a target of dopamine modulation. The aim of this study was to examine the actions of D2-like dopamine receptors (D2LRs) in this connection using rat brain slice preparations. Electrical stimulation of the frontal cortex evoked disynaptic inhibitory postsynaptic currents (IPSCs) in cesium-filled GPe neurons voltage-clamped at 0 mV. The IPSCs evoked by threshold stimulation were small,Keywords
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