ANALYSIS OF DIVERSITY OF MURINE ANTIBODIES TO DEXTRAN-B1355 .2. DEMONSTRATION OF MULTIPLE IDIOTYPES WITH VARIABLE EXPRESSION IN SEVERAL STRAINS
- 1 January 1977
- journal article
- research article
- Vol. 119 (4), 1406-1412
Abstract
Radioimmunoassays were developed that detect idiotypic (variable region) differences among the .alpha.(1 .fwdarw. 3) dextran-binding myeloma proteins U102, J558 and M104. An assay was also developed that detects variable region determinants common to all 3 proteins. Using these assays, 7S and 19S anti-.alpha.(1 .fwdarw. 3) dextran antibodies induced in 5 murine strains of the a1 IgCH linkage group and the recombinant strain BAB/14 were examined. All idiotypes were expressed in 19S and 7S antibodies from all strains, but with considerable strain-specific variability in penetrance. In 2 strains, 1 additional type of antibody, which lacked all 4 idiotypic determinants, generally constituted the bulk of total anti-.alpha.(1 .fwdarw. 3) dextran antibodies.This publication has 9 references indexed in Scilit:
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