Reagents and Synthetic Methods 17. Phenyl-Dichlorophosphate-Dimethylformamide Complex. Direct High Yield Annelation of Imines to Alpha-Phtalimido Beta-Lactams

Abstract

In recent years, the beta-lactams importance has been increased, specially for their antibiotical and chemical properties,^1–3 and for their use as synthetic intermediates^4,5. Several methods are available for the synthesis of beta-lactams^3,6–11. The most frequently used methods include the annelation of imines with activated substituted acetic acids as available starting materials^6,8.