GENETIC-CONTROL OF IMMUNE-RESPONSE IN RATS TO KNOWN SEQUENTIAL POLYPEPTIDE (TYR-GLU-ALA-GLY)N .1. ANTIBODY-RESPONSES

Abstract

In inbred rats, the antibody response to the known sequential polypeptide (Tyr-Glu-Ala-Gly)n abbreviated as (T-G-A-Gly)n, is under the control of 2 independently assorting loci; (co) dominant, Ag-B-linked Ir-(T-G-A-Gly) I, controlling qualitative responsiveness, and a non-Ag-B-linked modifier locus termed Ir-(T-G-A-Gly) II, controlling the level of antibody produced. The antibody response to (T-G-A-Gly)n was solely IgG [immunoglobulin G], and the level of antibody produced. The antibody response to (T-G-A-Gly)n was solely IgG [immunoglobulin G], and the level of antibody produced was dependent upon Ir-(T-G-A-Gly) II for phenotypic response type.