Formate metabolism in the vitamin B12-deficient rat
- 1 December 1959
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 73 (4), 732-735
- https://doi.org/10.1042/bj0730732
Abstract
An observed decrease in liver folic acid levels in the hyperthyroid rat is not corrected by vitamin B12 administration. It is also not accompanied by any clear-cut decrease in the incorporation of [Cl4]formate in vivo into the purines of liver acid-soluble nucleotides. It is concluded that incorporation of formate into the purines of rat liver acid-soluble nucleotides is independent of mild disturbances in folic acid metabolism. Vitamin B12 administration to a vitamin B12 deficient rat markedly decreased the incorporation of [C14]formate in vivo into liver acid-soluble nucleotides. This could be partly explained in terms of the accompanying increase in the oxidation of formate studied in vitro. Vitamin B12 has a role, directly or indirectly, in the oxidation of formate. In rat liver, oxidation of formate may not necessarily be catalase-linked.Keywords
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