Matrix Collagen of Devitalized Bone is Resistant to Osteoclastic Bone Resorption
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Connective Tissue Research
- Vol. 20 (1-4), 169-175
- https://doi.org/10.3109/03008208909023885
Abstract
The resorption of devitalized bone by isolated osteoclasts in culture was studied by scanning electron microscopy. Osteoclasts attached to the bone and resorbed mineral but left most of matrix collagen undigested in the resorption pits. Postculture-treatment of bone substrate with collagenase completely removed the matrix collagen in the resorption pits, whereas trypsin did not. The results suggest that native matrix collagen is resistant to osteoclastic attack in this in vitro model using devitalized bone.Keywords
This publication has 3 references indexed in Scilit:
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- A review of bone cell and substratum interactions: An illustration of the role of scanning electron microscopyScanning, 1985