Influence of Antihistamines on Mast Cell Disruption Following X-Irradiation.

Abstract

Total-body X-irradiation disrupts mast cells in the mesentery, skin and cheek pouch of rats and hamsters. Intraperitoneal injections of pyrilamine maleate (PM) (5 mg/kg/day) largely prevents this damage in the mesentery but not in the skin and cheek pouch of the hamster. In the irradiated rat PM is without protective effect. Promethazine hydro-chloride (PH) (5 mg/kg/day, intraperitoneally) does not protect against mast cell disruption in any tissue of the hamster. In dosages of 25 mg/kg/day PH causes marked disruption of mast cells in the mesentery but not in other tissues of the non-irradiated hamster.