Linkage of vancomycin and high-level gentamicin resistance genes on the same plasmid in a clinical isolate of Enterococcus faecalis

Abstract

A transferable 55-MDa plasmid which encoded resistance to both vancomycin and high concentrations of gentamicin was identified in a clinical isolate of Enterococcus faecalis. The plasmid hybridized with probes for the vanB and aac6' aph2” resistance genes. This is the first report of linkage of glycopeptide andhigh-level aminoglycoside resistance genes in an Enterococcus sp.