REDUCED GROWTH HORMONE RESPONSE TO GROWTH HORMONE‐RELEASING HORMONE IN CHILDREN WITH SIMPLE OBESITY: EVIDENCE FOR SOMATOMEDIN‐C MEDIATED INHIBITION
- 1 August 1987
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 27 (2), 145-153
- https://doi.org/10.1111/j.1365-2265.1987.tb01139.x
Abstract
SUMMARY: We have evaluated the plasma GH response to a single injection of 1μg/kg of GH‐releasing hormone (GHRH)‐40 in 15 obese children and 15 age‐matched control children. Most of the obese children showed a subnormal plasma GH response to GHRH and the mean plasma GH integrated area (IC‐GH) following stimulation was significantly smaller in obese than control children. Plasma somatomedin‐C (SM‐C) levels were significantly higher in obese than control children, and were negatively correlated with the peak plasma GH levels (r=−0.616, Pr=−0.554, P<0.02) after GHRH. Non‐esterified fatty acids (NEFA) and fasting plasma insulin levels were also elevated in obese children, but did not correlate with the extent of plasma GH response to GHRH. These data confirm previous observations on the refractoriness of obese children to release GH after GHRH, and imply that it may be due to the feedback inhibition operated by the elevated plasma levels of SM‐C.This publication has 32 references indexed in Scilit:
- Growth hormone response to hpGRF-40 in different forms of growth retardation and endocrine-metabolic diseasesEuropean Journal of Pediatrics, 1986
- Decreased prolactin secretion in childhood obesityThe Journal of Pediatrics, 1985
- Synthetic hpGRF 1–40 stimulates growth hormone and inhibits prolactin secretion in normal children and children with isolated growth hormone deficiencyPeptides, 1983
- Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the PituitaryScience, 1981
- IMPAIRED HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION IN MASSIVE OBESITYThe Lancet, 1979
- MANIFESTATIONS OF HYPOTHALAMIC OBESITY IN MAN: A COMPREHENSIVE INVESTIGATION OF EIGHT PATIENTS AND A EEVIEW OF THE LITERATUREMedicine, 1975
- Effect of nicotinic acid administration on plasma HGH, FFA and glucose in obese subjects and in hypopituitary patientsMetabolism, 1970
- Influence of growth hormone on the pathogenesis of obesity in childrenThe Journal of Pediatrics, 1970
- Effect of Nicotinic Acid Administration on Plasma Growth Hormone Concentrations.Experimental Biology and Medicine, 1967
- Effect of arginine on serum levels of insulin and growth hormone in obese subjectsMetabolism, 1967