LYNESTRENOL, AN AMPLIFIER OF LYMPHOCYTE STIMULATION

Abstract

Lynestrenol, a synthetic steroid progesterone-like substance, enhances the stimulation of normal human lymphocytes. It increases the phytohemagglutinin response and the mixed-lymphocyte cultures. This augmentation can, in some cases, be > 100% of the phytohemagglutinin or mixed lymphocyte reaction baseline. There is no significant effect on the pokeweed mitogen stimulation. It is concluded that lynestrenol can modulate, in vitro, some T [thymus-derived] cell functions.