SHORT-LIVED MUTAGEN IN SALMONELLA PRODUCED BY REACTION OF TRICHLOROACETIC ACID AND DIMETHYL SULPHOXIDE
- 1 March 1980
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Genetics and Cytology
- Vol. 22 (1), 35-40
- https://doi.org/10.1139/g80-006
Abstract
A chemical reaction occurs when trichloroacetic acid (TCA) is dissolved in dimethyl sulphoxide (DMSO), with the production of a short-lived mutagenic derivative which was detected using the Salmonella/mammalian-microsome plate overlay assay. Other interactions between test chemicals and solvents are discussed. Choice of proper solvents in mutagenicity testing is emphasized.Keywords
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