Simmonds’ Disease with a Cranio-Pharyngioma

Abstract

A case of Simmonds'' disease is reported. The patient, a white unmarried [female], aged 26 had retarded growth, polydipsia and polyuria, mental retardation, hypotension, impaired vision and ocular disturbances, dry skin, pathological sleep, depressed B.M.R. with hypo-pyrexia and absence of secondary sex characteristics. There was no cachexia. The ocular disturbances, the hypersom-nolence, and the temperature and water aberrations suggested pressure on the optic chiasm and hypothalamus. At necropsy a craniopharyngioma (Erdheim tumor) was found. There was generalized microsplanchnia.