Glomerular Lesions in the Acquired Immunodeficiency Syndrome

Abstract

Between Jan. 1982 and Dec. 1983, 75 patients with the acquired immunodeficiency syndrome were identified in hospitals: 35% used i.v. drugs, 50% had proteinuria in excess of 0.5 g/dl, and 10% were nephrotic. Glomerular changes seen at autopsy in 36 patients included frequent mesangial lesions and deposits associated with mild asymptomatic proteinuria. Focal and segmental glomerular sclerosis was found in 5 patients and 4 of these had the nephrotic syndrome. Whereas reversible episodes of acute renal failure were not uncommon, terminal episodes of acute renal insufficiency occurred in 14 patients. The short survival of these patients may prevent the development of chronic renal failure.