Antithrombin III and Diseases
- 1 July 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 48 (1), 69-80
- https://doi.org/10.1093/ajcp/48.1.69
Abstract
A reliable uncomplicated method for the determination of antithrombin III (serum antithrombin) is described. Its results are independent of antithrombin II activity. Antithrombin III activity, significantly lower than in normal individuals, was observed in patients with a tendency to intravascular clotting and in diseases of the liver. Significantly higher levels were seen after homotransplantation of the kidney, during treatment with prothrombin-depressing agents, and in some patients with valvular heart disease. The independence of antithrombin III activity from the rate of thrombin generation is demonstrated, and the significance of antithrombin III activity is discussed.This publication has 10 references indexed in Scilit:
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