Immunologic dysfunction in the pathogenesis of periodontal diseases*
- 1 October 1987
- journal article
- review article
- Published by Wiley in Journal of Clinical Periodontology
- Vol. 14 (9), 489-498
- https://doi.org/10.1111/j.1600-051x.1987.tb00989.x
Abstract
Despite significant progress in our understanding of the pathogenesis and etiology of periodontal diseases, the nature and contribution of the immune system to this disorder remains unclear. Several studies provide evidence for either a protective or destructive role. These conflicting findings are difficult to reconcile, since most interpretations tend to argue for a static contributory role (i.e., either protective or destructive) of the immune system. Current theories on the role of the immune response do not address these conflicting findings as well as the contradictory observation of a detectable immune response in the face of persistent infection in these patients. In this article, we present a model, based on available data, for the contribution of the immune system to the pathogenesis of periodontal disease. This model ascribes a dynamic role for the immune response. As documented in other infectious diseases, it is entirely possible, for example, that a state of immunologic dysfunction may occur in the earliest stages of periodontal disease progression; this may then be followed by a period of active immune reactivity (humoral and/or cellular) that would represent either a delayed or depressed response. This model is discussed in conjunction with recent findings that several suspected periodontal pathogens are capable of producing immunosuppressive agents. Many of the apparently contradictory clinical observations concerning the host immune response to oral pathogens and its correlation (or lack of) with both the progression and severity of periodontal disease may be accounted for in this model.Keywords
This publication has 117 references indexed in Scilit:
- Serum antibodies in young adult humans reactive with periodontitis associated treponemesJournal of Periodontal Research, 1985
- IMMUNE COMPLEXES SUPPRESS CELLULAR IMMUNITYAnnals of the New York Academy of Sciences, 1984
- The Primary ImmunodeficienciesNew England Journal of Medicine, 1984
- The Primary ImmunodeficienciesNew England Journal of Medicine, 1984
- Experimental Periodontal Disease: Immediate HypersensitivityThe Journal of Periodontology, 1983
- Polyclonal B-cell activation: Severe periodontal disease in young adultsClinical Immunology and Immunopathology, 1980
- Polyclonal activation: A form of primitive immunity and its possible role in pathogenesis of inflammatory diseasesDevelopmental & Comparative Immunology, 1978
- Alveolar Bone Loss in Thymectomized Golden HamstersThe Journal of Periodontology, 1977
- Lymphoproliferative Response during Resolution and Recurrence of Naturally Occurring GingivitisThe Journal of Periodontology, 1977
- Human Lymphoproliferative Reaction to Saliva and Dental Plaque‐Deposits: An In Vitro Correlation with Periodontal DiseaseThe Journal of Periodontology, 1972