STUDIES IN ISO-UREAS AND ISO-UREIDES: I. SOME NEW ISO-UREAS; SALTS AND ACYL DERIVATIVES

Abstract

In this investigation a series of new iso-urea ethers has been prepared by the general reaction of addition of alcohols to cyanamide in the presence of dry hydrogen chloride. Where the hydrochlorides of the iso-ureas were difficult to isolate and purify, conversion to the salicylates gave excellent results. The new iso-ureas were further characterized by condensing them with methyl malonate to form iso-urea salts of 2-alkoxy-barbituric acids, from which the acids themselves could be easily liberated by the addition of dilute mineral acid. A few open-chain acyl derivatives were also prepared.