A Study of the Effect of Deoxypyridoxine or Isonicotinic Acid Hydrazide upon Tissue Potassium and Sodium Content of Pyridoxine-Deficient Male Rats

Abstract

Seven groups of 4 rats each were fed a pyridoxine-free basal diet or the basal diet plus either deoxypyridoxine (DOP) isonicotinic acid hydrazide (INH) or pyridoxine. Based upon K and Na assays of liver, kidney, brain, muscle, heart, blood plasma and blood cells, the following observations were made: When vitamin B₆-deficient animals were compared with vitamin B₆-adequate animals, Na content remained constant or decreased and K content remained constant or increased in all tissues studied except heart and blood cells, where a tendency toward opposite effects was noted. When DOP-treated vitamin B₆-deficient animals were compared with vitamin B₆-deficient animals, Na content remained constant or increased and K content remained constant or decreased in all tissues except heart and blood plasma, where a tendency toward opposite effects was noted. When INH-treated vitamin B₆-deficient animals were compared with vitamin B₆-deficient animals, Na content remained constant or increased and K content remained constant or decreased in all tissues except kidney, muscle and blood plasma and blood cells where a tendency toward opposite effects was noted.