THE PHARMACOLOGY OF PROPIONYL ATROPINE METHYL NITRATE

Abstract

A series of esters of atropine and hyoscine, both in the tertiary and quaternary form, have been examined for their muscarinic and ganglionic blocking and neuromuscular transmission inhibiting activity. In addition the effect on the gastric secretion has been studied by the Shay rat method. Figures are also given for toxicities. In general, the pharmacology of the quaternary derivatives is qualitatively and quantitatively the same as the parent substances. The quaternary compounds retain a considerable amount of their tertiary activity but in addition become relatively strong ganglionic blocking agents. Most of the compounds reduce the volume and acidity of the gastric juice.